Am J Orthod Dentofacial Orthop. 2025 Sep 19:S0889-5406(25)00333-6. doi: 10.1016/j.ajodo.2025.07.012. Online ahead of print.

ABSTRACT

INTRODUCTION: This study aimed to establish a consensus, thanks to the participation of a large group of experts in the field of aligner therapy, on several of its clinical and extraclinical aspects, with particular reference to its potential and biomechanical limitations.

METHODS: A Delphi study was conducted in 3 rounds. On the basis of the most recent systematic reviews in the literature, the steering committee formulated 35 questions. A group of 36 international experts agreed to participate in the survey and were asked to respond to the questions, choosing their level of agreement on a scale of 1-5 in the first round, then from 1 to 3 in the second, and finally with a yes or no response in the third, progressively narrowing the field of research. The items for which consensus (≥70%) was obtained were accepted; the others were reformulated.

RESULTS: On the basis of the analysis of the experts’ responses, 68 questions were reformulated for the second round and 28 for the third round. After 3 rounds, the study generated 47 consensus statements regarding biomechanical aspects and extraclinical factors.

CONCLUSIONS: The study, based on the modified Delphi method, collected the opinion of experts, comparing it with the scientific literature to evaluate the potential and limitations of orthodontic aligners, obtaining 47 consensus statements related to biomechanics and extraclinical factors.

PMID:40970859 | DOI:10.1016/j.ajodo.2025.07.012

Sensors (Basel). 2025 May 31;25(11):3476. doi: 10.3390/s25113476.

ABSTRACT

Oral caries is one of the most common oral diseases worldwide, affecting about 2.4 billion people. This phenomenon always starts with enamel demineralization, eventually progressing to tooth cavitation and loss when not properly treated. Nowadays, the standard diagnostic techniques to detect demineralization strongly depend on the operator’s expertise and are characterized by fairly low sensitivity and specificity, and/or involve ionizing radiation. This study investigates the feasibility of a non-invasive, effective, rapid, and radiation-free approach employing impedance spectroscopy for early caries detection. Two binary classifiers were developed for automated assessment and validated using a dataset obtained by in vitro demineralization of human teeth. A computationally efficient single-neuron classifier, utilizing a single impedance phase measurement at 15 Hz, achieved 88% accuracy, offering a lightweight, low-power solution suitable for microcontroller implementation and rapid measurements. A Multi-Layer Perceptron (MLP) classifier, utilizing equivalent circuit element values, yielded a similar accuracy of 86%. A prototype of a diagnostic portable tool was developed and characterized, demonstrating reliable impedance phase measurement (uncertainty < 2°). The performance of these classifiers meets or exceeds the existing AI-based methodologies for caries detection relying on radiographic data. This work introduces a novel application of AI to tooth impedance spectra, addressing a significant research gap in non-invasive diagnostics and laying the foundation for a novel, accessible, and accurate tool for early caries management.

PMID:40969076 | DOI:10.3390/s25113476

Cranio. 2025 Sep 4:1-8. doi: 10.1080/08869634.2025.2552537. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim of this study was to investigate the impact of rapid maxillary expansion (RME) on sleep bruxism (SB) and respiratory indexes in pediatric patients.

METHODS: Twenty-four subjects needing orthodontic treatment and with suspicion of obstructive sleep apnea (OSA) were recruited. Before orthodontics, a clinical and anamnestic evaluation as well as a polygraphic recording was performed. The subjects underwent rapid palatal expansion and, after 6 months, the evaluations were repeated for the participants with an apnea-hypopnea index (AHI) > 1.

RESULTS: Mean AHI was 2.3±1.4 and 2.2±1.2 at T0 and T1, respectively, while sleep bruxism events (SBEs) values were 15.1± 17 and 23.1±14.5. No significant differences between pre and post treatment values could be detected.

CONCLUSIONS: At the study population level, no statistically significant differences in the main (i.e., AHI and SBEs) and secondary outcomes with RME treatment were described. Specific phenotypes might be identified with future studies.

PMID:40908797 | DOI:10.1080/08869634.2025.2552537

J Clin Orthod. 2025 Jul;59(7):452-459.

NO ABSTRACT

PMID:40889495

J Orofac Orthop. 2025 Aug 19. doi: 10.1007/s00056-025-00609-7. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to compare the accuracy of orthodontic tooth movements achieved with three-dimensionally (3D) printed aligners (Noxi, Sweden&Martina, Due Carrare, Padova, Italy) using a 12 h/day protocol with that of thermoformed aligners (F22 aligner, Sweden&Martina, Due Carrare, Padova, Italy) using a 22 h/day protocol.

METHODS: Of the 40 white adult patients (12 men and 28 women, mean age 30.1 years) undergoing orthodontic treatment with aligners selected based on specific inclusion criteria, 20 patients were treated with Noxi aligners using a 12 h/day protocol (study group), and the remaining 20 patients were treated with F22 aligners using a 22 h/day protocol (control group). Pretreatment, ideal posttreatment (as planned in the setup), and real posttreatment digital models were analyzed using VAM software (Vectra, Canfield Scientific, Fairfield, NJ, USA). Angular and linear measurements were evaluated to measure mesiodistal tipping, vestibulolingual tipping, and rotational movements for 1120 teeth. Data were compared to evaluate treatment accuracy for each tooth, with statistical analysis of the results.

RESULTS: No statistically significant differences in accuracy emerged between the study group (64.2%) and the control group (65.4%) for any type of tooth movement or tooth category. In the study group, vestibulolingual tipping showed the highest predictability (69.63%), followed by mesiodistal tipping (65.38%) and rotation (60.5%). In the control group, the vestibulolingual and mesiodistal movements showed the highest predictability, with a mean accuracy of about 67%, followed by rotation (62.3%).

CONCLUSION: Despite the reduced collaboration request, the group treated with Noxi aligners did not show any significant differences compared to the group treated with F22 aligners with regard to percentage accuracy for all analyzed orthodontic movements.

PMID:40828392 | DOI:10.1007/s00056-025-00609-7

Eur Heart J Digit Health. 2025 May 30;6(4):733-741. doi: 10.1093/ehjdh/ztaf056. eCollection 2025 Jul.

ABSTRACT

AIMS: The APOLLO-QR (APPlying smartphOne for piLLs intake cOnfirmation by QR code reading) study assessed the congruence between a quick response (QR) code-based digital self-reporting and pill count in measuring medication adherence.

METHODS AND RESULTS: The APOLLO-QR pilot, observational study prospectively included patients owning a smartphone accepting to undergo a home-telemonitoring of ticagrelor adherence by sending feedback of each pill intake through an email generated by framing a QR code placed on the medication packaging. Ticagrelor adherence was measured at 1 and 3 months by pill count allowing to calculate accuracy of the digital self-reporting in estimating drug adherence by assessing the correspondence between the number of received feedback emails and the number of pills taken from those prescribed. Among 109 patients, 30-day adherence to ticagrelor was 98.6 ± 2.6% as measured by pill count vs. 88.9 ± 10.4% as assessed by the number of feedback emails sent by the digital self-reporting, which provided an accuracy in estimating drug adherence of 90.1 ± 10.1%. Similar results were achieved at three months among the 95 patients (87.2%) continuing the study. Only nine patients (8.3%) missed sending four consecutive feedback emails of whom three (2.8%) had voluntarily discontinued ticagrelor within 1 month. A high patient satisfaction emerged from responses to a questionnaire showing that tested telemonitoring was consistently perceived as easy, convenient, and useful, although the need for more interactivity was suggested.

CONCLUSION: The QR code-based self-reporting of pill intake showed a high accuracy in estimating medication adherence and yielded a good patient satisfaction, suggesting a potential for its clinical applicability.

PMID:40703142 | PMC:PMC12282341 | DOI:10.1093/ehjdh/ztaf056

J Clin Orthod. 2025 Apr;59(4):1000.

NO ABSTRACT

PMID:40296748

J Clin Orthod. 2025 Feb;59(2):107-108.

NO ABSTRACT

PMID:40295180

Eur Heart J Suppl. 2025 Apr 16;27(Suppl 3):iii60-iii63. doi: 10.1093/eurheartjsupp/suaf017. eCollection 2025 Mar.

ABSTRACT

Transcatheter edge-to-edge repair (TEER) is currently indicated in symptomatic patients with severe functional mitral regurgitation (MR) who are not eligible for surgery and who have a high likelihood of responding to treatment. This recommendation is based on two randomized trials suggesting that the benefits of TEER may be limited to patients with severe MR, defined by an effective regurgitant orifice area (EROA) ≥0.40 cm², and a non-excessively remodelled left ventricle. The randomized RESHAPE-HF2 study recently showed that compared to medical therapy alone, treatment with TEER by MitraClip in patients with symptomatic heart failure and less severe functional MR, with lower EROA (mean 0.23 cm²), is associated with a significant reduction in hospitalizations for heart failure, and an improvement in symptoms and quality of life, without a clear benefit on mortality. However, within the cohort of patients with less severe MR enrolled in the RESHAPE-HF2 study, the benefits of MitraClip compared to medical therapy alone seem more significant in selected patients with characteristics associated with a higher risk of heart failure exacerbation, suggesting the importance of careful selection of patients with symptomatic heart failure and MR who could benefit from TEER.

PMID:40248280 | PMC:PMC12001762 | DOI:10.1093/eurheartjsupp/suaf017

BMC Oral Health. 2025 Apr 11;25(1):533. doi: 10.1186/s12903-025-05863-0.

ABSTRACT

BACKGROUND: Thermoplastic materials, such as glycol-modified polyethylene terephthalate (PET-G) and thermoplastic polyurethane (TPU), undergo alterations due to environmental factors in the oral cavity, which can affect their composition and surface properties over time. While previous studies have explored these changes, a comprehensive characterization of TPU and PET-G properties, particularly after immersion in artificial saliva, remains limited. This study aimed to evaluate the aging process of 24 TPU and 24 PET-G dumbbell-shaped specimens before and after exposure to artificial saliva. The analysis focused on the morphological, chemical, and optical properties of the samples, including thickness, weight, and surface roughness.

METHODS: The study examined 48 thermoplastic samples, equally divided between PET-G and TPU. The samples were thermoformed into standardized shapes and analyzed at three time points: after thermoforming (T0), after 7 days (T1), and after 14 days (T2) of immersion in artificial saliva at 37 °C. Measurements included weight, thickness, surface roughness, absorbance, and Fourier transform infrared spectroscopy (FTIR). Data were analyzed using one-way ANOVA to identify significant changes over time, with a significance level of p < 0.01.

RESULTS: Both materials exhibited significant reductions in surface roughness, with TPU showing a decrease in average roughness (Ra) from 99.43 nm at T0 to 76.53 nm at T2 (-23.02%) and PET-G decreasing from 33.25 nm to 20.19 nm (-39.27%). The root mean square roughness (Rq) in TPU declined by 41.67% (from 126.91 nm to 74.02 nm), while PET-G showed a reduction of 28.06% (from 44.98 nm to 32.35 nm). Peak-to-valley roughness (Rt) also decreased by 10.5% in TPU and 27.96% in PET-G. No statistically significant changes were observed in thickness, weight, optical density, or chemical composition (p > 0.01). The roughness disparity between TPU and PET-G persisted even after immersion in saliva.

CONCLUSIONS: Following the simulated intraoral aging process, significant changes in surface roughness were observed in TPU and PET-G specimens. The reduction in roughness, particularly a 39.27% decline in PET-G and 23.02% in TPU, has been clinically associated with decreased plaque accumulation and reduced friction between the aligner and the teeth.

PMID:40217188 | DOI:10.1186/s12903-025-05863-0